Research Article

Inflammation, Oxidative Stress, and Chronic Unpredictable Mild Stress Model of Depression

Authors

  • Vlad Dionisie Assistant Lecturer, Department of Psychiatry and Psychology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania

Abstract

Depression is one of the most common psychiatric disorders. Animal models represent a valuable research tool to investigate the molecular pathogenic mechanisms of depression and to develop and test different possible antidepressant drugs. Therefore, several murine models have been established, but the chronic unpredictable mild stress model has robust evidence. Inflammation and oxidative stress pathways have a clear involvement in the complex and intricate pathophysiology of depression, with strong evidence coming from studies using the chronic unpredictable mild stress model. This review provides an overview of the characteristics of the chronic, unpredictable mild stress model of depression and its role in investigating inflammation and oxidative stress pathways in depression.

Article information

Journal

Journal of Medical and Health Studies

Volume (Issue)

5 (2)

Pages

71-75

Published

2024-05-24

How to Cite

Dionisie, V. (2024). Inflammation, Oxidative Stress, and Chronic Unpredictable Mild Stress Model of Depression. Journal of Medical and Health Studies, 5(2), 71-75. https://doi.org/10.32996/jmhs.2024.5.2.9

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Keywords:

Depression, Oxidative Stress, Inflammation, Cronic stress, animal model