The Effect of Aerobic Exercise against D-galactose and AlCl3-induced Hepatosteatosis in Mus Musculus C57BL/6J

Abstract

In the 21st century, sedentary habits and consumption of caramelized food packed in aluminium foil made the oxidative state on the body. There are differences in opinions about aerobic exercise and its effects on inflammation and oxidative stress. This research aims to compare the liver histologic pattern between the group which was given aerobic exercise and not given after being induced with D-galactose and AlCl₃.
.: This research used an experimental method using two groups of Mus musculus C57BL/ which was injected with D-galactose (90 mg/kg body weight) and AlCl₃ (40 mg/kg body weight). The control group was only injected with those substances. The aerobic group was intervened with swimming for 30 minutes each day (6 days a week). After being sacrificed, HE staining was done in the liver specimens to evaluate the bile duct proliferation and steatosis changes. There were significant differences in biliary duct proliferation (p = 0.043) and steatosis changes (p = 0.043) in an aerobic group compared to the control group. Aerobic exercise which was conducted 30 minutes for 6 days a week showed more bile duct proliferation and increased steatosis changes.