Frequency of Vitamin D Deficiency Among Patients of Multiple Sclerosis in Pakistan
Keywords:Multiple Sclerosis, Vitamin D deficiency, 25(OH)D levels,risk, central nervous system.
Multiple Sclerosis (MS) is a very common chronic demyelinating disorder of the central nervous system particularly among adults. In this study we aim to determine the frequency of vitamin D deficiency in patients of multiple sclerosis identifying such patients and providing proper treatment if needed, would help reducing the morbidity associated with MS. We conducted this study from August 2018 to February 2109 at Department of Neurology, Jinnah Postgraduate Medical Center Karachi. A total of 114 previously diagnosed patients of Multiple sclerosis were included in this study. Blood was drawn and sent for measurement of 25(OH)D levels. Patients was labeled as having vitamin D deficiency if the level of total 25(OH)D level was < 20ng/ml. The average age of the patients was 37.74±10.73 years. Frequency of vitamin D deficiency in patients of multiple sclerosis was 36.44% (42/114). Out of 42 deficient cases, 34(80.9%) were mildly deficient and 8(19.1%) were moderately deficient in Vitamin D. supplementation of vitamin D in healthy individuals is now being considered as a potent strategy for MS prevention. In utero and early-life exposure could also be important, but there is strong evidence that levels of vitamin D during end of adolescence and beginning of adulthood have a major effect in determining the risk of MS.
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