Research Article

Acute Graft-Versus-Host Disease: A Comprehensive Review of Management and Recent Advances

Authors

  • Salman Khan Division of Hematology and Medical Oncology, Mayo Clinic Florida, Jacksonville, FL, USA: Public Health, University of Massachusetts, Amherst, MA, USA
  • Seemab Sheikh Community Health Center, New Britain, Connecticut, USA
  • Fnu Vishal Rochester Regional Health

Abstract

Acute graft-versus-host disease (GVHD) is a severe complication that can arise after allogeneic hematopoietic cell transplantation (alloHCT), a life-saving procedure for various hematological malignancies and bone marrow disorders. GVHD occurs when donor immune cells recognize the recipient's tissues as foreign and start an immune response, leading to tissue damage and inflammation. Our objectives are to enhance understanding, prevention, and treatment strategies for acute GVHD. We employ an integrated approach involving epidemiology, risk factors, and clinical trial insights. Key findings highlight persistent challenges in GVHD incidence, particularly concerning HLA disparities and ethnicity's role. Acute GVHD remains associated with high mortality rates, emphasizing the need for improved strategies. We explore the disease's phases and discuss promising biomarkers for early diagnosis and prognosis. Our research underscores the importance of a multifaceted approach to GVHD management, ultimately contributing to enhanced patient care.

Article information

Journal

Journal of Medical and Health Studies

Volume (Issue)

4 (5)

Pages

68-72

Published

2023-09-29

How to Cite

Khan, S., Sheikh, S., & Vishal, F. (2023). Acute Graft-Versus-Host Disease: A Comprehensive Review of Management and Recent Advances. Journal of Medical and Health Studies, 4(5), 68-72. https://doi.org/10.32996/jmhs.2023.4.5.10

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Keywords:

Acute Graft-Versus-Host Disease, Allogeneic hematopoietic cell transplantation, Acute GVHD management