Research Article

Integrating Machine Learning and Deep Learning Techniques for Advanced Alzheimer’s Disease Detection through Gait Analysis

Authors

Abstract

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that severely affects cognitive and motor functions, necessitating early detection for timely intervention and improved patient outcomes. Subtle changes in gait, including stride length and cadence, have been identified as potential early indicators of cognitive decline associated with AD (Del Din et al., 2019). This study leverages advanced deep learning methodologies to enhance the diagnostic capability of gait analysis. Using datasets collected from wearable sensors and motion capture systems, Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs) were implemented to classify individuals as healthy or at risk for AD. Evaluation metrics, including accuracy, precision, and recall, demonstrated superior performance of deep learning models compared to traditional diagnostic approaches, achieving over 90% classification accuracy in detecting early-stage AD (Esser et al., 2021). These results highlight the transformative potential of AI in healthcare, particularly in non-invasive diagnostic tools for neurodegenerative diseases.

Article information

Journal

Journal of Business and Management Studies

Volume (Issue)

7 (1)

Pages

140-147

Published

2025-01-28

How to Cite

Sarkar, M. (2025). Integrating Machine Learning and Deep Learning Techniques for Advanced Alzheimer’s Disease Detection through Gait Analysis. Journal of Business and Management Studies, 7(1), 140-147. https://doi.org/10.32996/jbms.2025.7.1.8

References

[1] Del Din, S., Galna, B., Godfrey, A., & Rochester, L. (2019). Gait analysis in neurodegenerative diseases: An overview of wearable sensors and emerging technologies. Journal of NeuroEngineering and Rehabilitation, 16(1), 101. https://doi.org/10.1186/s12984-019-0582-8

[2] Esser, P., Dawes, H., Collett, J., & Howells, K. (2021). Wearable sensor-based gait analysis in neurological disorders: A systematic review and meta-analysis. Journal of NeuroEngineering and Rehabilitation, 18(1), 50. https://doi.org/10.1186/s12984-021-00855-6

[3] Md Abu Sayed, Duc Minh Cao, Maliha Tayaba, MD Tanvir Islam, Md Eyasin Ul Islam Pavel, Md Tuhin Mia, Eftekhar Hossain Ayon, Nur Nobe, Bishnu Padh Ghosh, & Malay Sarkar. (2023). Parkinson's Disease Detection through Vocal Biomarkers and Advanced Machine Learning Algorithms. Journal of Computer Science and Technology Studies, 5(4), 142-149. https://doi.org/10.32996/jcsts.2023.5.4.14

[4] MDPI Sensors. (2023). A Comprehensive Framework for Gait Analysis Using Wearable Sensors in Alzheimer’s Disease Detection. Sensors, 23(9), 4184. https://www.mdpi.com/1424-8220/23/9/4184

[5] Chawla, N. V., Bowyer, K. W., Hall, L. O., & Kegelmeyer, W. P. (2002). SMOTE: Synthetic Minority Over-sampling Technique. Journal of Artificial Intelligence Research, 16, 321–357. https://doi.org/10.1613/jair.953

[6] Esser, P., Dawes, H., Collett, J., & Howells, K. (2021). Wearable sensor-based gait analysis. Journal of NeuroEngineering and Rehabilitation, 18(1), 50. https://doi.org/10.1186/s12984-021-00855-6

[7] Fawcett, T. (2006). An introduction to ROC analysis. Pattern Recognition Letters, 27(8), 861–874. https://doi.org/10.1016/j.patrec.2005.10.010

[8] Hastie, T., Tibshirani, R., & Friedman, J. (2009). The Elements of Statistical Learning: Data Mining, Inference, and Prediction. Springer. https://doi.org/10.1007/978-0-387-84858-79

[9] Wang, W., Lee, J., Harrou, F., & Sun, Y. (2020). Early detection of Parkinson’s Disease. IEEE Access, 8, 147635–147646. https://doi.org/10.1109/ACCESS.2020.3016062

[10] Yang, X., Ye, Q., Cai, G., Wang, Y., & Cai, G. (2022). PD-ResNet for classification of Parkinson’s Disease. IEEE Journal of Translational Engineering in Health and Medicine, 10, 2200111. https://doi.org/10.1109/JTEHM.2022.3180933

[11] Zhao, A., Qi, L., Li, J., Dong, J., & Yu, H. (2018). Detection of Parkinson’s Disease from gait data. Neurocomputing, 315, 1–8. https://doi.org/10.1016/j.neucom.2018.06.065

[12] Braga, D., Madureira, A. M., & Coelho, L. (2019). Speech processing for neurodegenerative disorders. Engineering Applications of Artificial Intelligence, 77, 148-158.

[13] MDPI Sensors. (2023). Wearable sensor-based gait analysis. Sensors, 23(9), 4184. https://www.mdpi.com/1424-8220/23/9/4184

[14] Doshi-Velez, F., & Kim, B. (2017). Towards a rigorous science of interpretable machine learning. arXiv preprint arXiv:1702.08608. https://arxiv.org/abs/1702.08608

[15] Sarkar, M., Rashid, M. H. O., Hoque, M. R., & Mahmud, M. R. (2025). Explainable AI In E-Commerce: Enhancing Trust And Transparency In AI-Driven Decisions . Innovatech Engineering Journal, 2(01), 12–39. https://doi.org/10.70937/itej.v2i01.53

[16] MD. Ekramul Islam Novel, Malay Sarkar, & Aisharyja Roy Puja. (2024). Exploring the Impact of Socio-Demographic, Health, and Political Factors on COVID-19 Vaccination Attitudes. Journal of Medical and Health Studies, 5(1), 57-67. https://doi.org/10.32996/jmhs.2024.5.1.8

[17] Aisharyja Roy Puja, Rasel Mahmud Jewel, Md Salim Chowdhury, Ahmed Ali Linkon, Malay Sarkar, Rumana Shahid, Md Al-Imran, Irin Akter Liza, & Md Ariful Islam Sarkar. (2024). A Comprehensive Exploration of Outlier Detection in Unstructured Data for Enhanced Business Intelligence Using Machine Learning. Journal of Business and Management Studies, 6(1), 238-245. https://doi.org/10.32996/jbms.2024.6.1.17

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Keywords:

Deep Learning, Gait Analysis, Alzheimer’s Disease, Neurodegenerative Disorders, Early Detection, Wearable Sensors, Spatiotemporal Data