The relationship of hydrogen bond formation with solubility increment of poorly soluble drugs

Abstract

The study of drug solubility provides an information about the structure and the  nature and strength of intermolecular forces of drug molecules. There are different augmentation techniques for improvement of the solubility of the poorly soluble compounds. These techniques can improve their solubility by different mechanisms. One of them including the formation of intermolecular hydrogen bonds between the drug and another hydrophilic compound or solvent. Also these bonds can be resulted from change the drug structure into a salt or prodrug form. Which has more tendency for intermolecular hydrogen bonding with water molecules. Hence will largely increases their solubility. Others include only break or weakened the intramolecular hydrogen bonding that is present among the molecules of these drugs.