The Protective Role of Vitamin E on the Liver, Kidney, and Male Reproductive Functions of Paracetamol Overdose in Male Rabbits

Abstract

Pharmaceutical harm may result from both planned effects and pharmaceutical errors. Although paracetamol is often used as an antipyretic and painkiller, an excessive amount of it may be toxic to the liver and create free radicals that are harmful to human health. Thirty adult male rabbits were divided into three groups. Group I was orally administered normal saline (control). Group II (Paracetamol toxic dose) was orally administered paracetamol (1500mg /kg b.w ) dissolved in normal saline. Group III (Paracetamol & vitE)  (1500;400)mg/kg b.w), respectively. All group doses were given for three weeks daily. The findings revealed that a toxic dose of paracetamol increased oxidative stress (MDA), liver enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AS.T), alkaline phosphatase (ALP), the levels of serum creatinine (Cr), urea, and blood urea nitrogen (BUN), and decreased testosterone hormone. Additionally, the findings revealed a notable improvement in the liver and kidney functions. This study demonstrates that paracetamol in overdose elevated oxidative stress and hepatotoxicity, and nephrotoxicity reduced testosterone hor, but on the other hand, vitamin E had a protective effect of eliminating this disruptor.