Research Article

Ethyl Acetate Fraction of Momordica Charantia L. Fruits Induce the Phagocytosis Activity and Capacity of Rat Peritoneal Macrophages

Authors

  • Rachmi Ridho Pharmaceutical Sciences, Faculty of Pharmacy, Pancasila University, South Jakarta Indonesia; Faculty of Health Sciences and Pharmacy, Gunadarma University, Depok City, Indonesia
  • Chaidir Chaidir Pharmaceutical Sciences, Faculty of Pharmacy, Pancasila University, South Jakarta, Indonesia
  • Lusi Nursilawati Syamsi Pharmaceutical Sciences, Faculty of Pharmacy, Pancasila University, South Jakarta, Indonesia
  • Bambang Pontjo Priosoeryanto Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences IPB University, Bogor, Indonesia
  • Esti Mumpuni Department of Chemistry, Faculty of Pharmacy, Pancasila University, South Jakarta, Indonesia
  • Syamsudin Abdillah Department of Pharmacology, Faculty of Pharmacy, Pancasila University, South Jakarta, Indonesia

Abstract

Phagocytosis is one of the body's immune mechanisms in the elimination of antigens, including bacteria. Its mechanism is affected by many factors, such as the inducers. The present study aims to elaborate on the effect of ethyl acetate fraction of Momordica charantia L fruits on the activity and capacity of rat peritoneal macrophages on a non-A Staphylococcus aureus, including the white blood cell percentage. A series of M. charantia ethyl acetate extract concentrations of 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW were used to identify the phagocytosis activity and capacity, as well as the percentage of white blood cells (WBC). The result showed that the concentration of 50 mg/kg BW had the highest phagocytic activity and capacity compared to other concentrations (P < 0.05), while for the WBC percentage, there were no significant differences among the concentrations (P > 0.05). The conclusion of the present study is M. charantia ethyl acetate extract has the potential to be used as a natural immunostimulant.

Article information

Journal

Journal of Medical and Health Studies

Volume (Issue)

5 (2)

Pages

16-25

Published

2024-03-29

How to Cite

Ridho, R., Chaidir, C., Syamsi, L. N., Priosoeryanto, B. P., Mumpuni, E., & Abdillah, S. (2024). Ethyl Acetate Fraction of Momordica Charantia L. Fruits Induce the Phagocytosis Activity and Capacity of Rat Peritoneal Macrophages. Journal of Medical and Health Studies, 5(2), 16-25. https://doi.org/10.32996/jmhs.2024.5.2.2

Downloads

Views

15

Downloads

5

Keywords:

Ethyl acetate fraction, Momordica charantia, phagocytosis, white blood cells, immunostimulant