Myeloid Cell Leukemia-1 (MCL-1) and Its Correlation with the Prognostic Scoring System in Chronic Myeloid Leukemia

Abstract

The prognostic scoring system is used to assess the prognosis of Chronic Myeloid Leukemia (CML) patients to get the right treatment strategy. Poor prognosis, treatment resistance, and tumorigenesis have been associated with the overexpression of Myeloid Cell Leukemia-1 (MCL-1), an anti-apoptotic protein in several hematologic malignancies, including CML. Research on the correlation between MCL-1 levels and the scoring system prognostic in patients with CML is still limited. This study aims to evaluate the correlation between MCL-1 levels and the prognostic scoring system in chronic phase CML patients. This research was conducted on chronic phase CML patients who came to the Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Hasan Sadikin Hospital Bandung, Indonesia. Data is collected from medical records of patients examined for MCL-1 protein levels from previous studies and results of prognostic scoring systems (Sokal, Hasford, and EUTOS. Data were analyzed to evaluate the correlation between the MCL-1 level and the prognostic scoring system. Forty patients had a male-female ratio of 1.5. The average age is 40±11 years, with an age range of 19 to 61 years. The median MCL-1 protein level was 0.27 (min 0.02-max 4.1). Statistical analysis showed no significant correlation between MCL-1 levels and Sokal, Hasford, and EUTOS scores in chronic phase CML patients (p=0.285; p=0.923 and p=0.663, respectively).