The Role of Histopathology in Patients with Hepatitis C Leading to Hepatocellular Carcinoma

Abstract

Hepatocellular carcinoma (HCC) is a primary malignant tumor of the liver, where 90% of cases of primary liver tumors are caused by this tumor. About 85% of HCC tumor cases also have cirrhosis of the liver. Currently, HCC is the fifth most malignant tumor in the world. Other than that, San HCC's survival is scanty. A patient at Dr. Soetomo complained of an enlarged stomach 5 months ago. The patient was first diagnosed with Hepatitis C 3 months ago but has not been treated for hepatitis C. The patient underwent several examinations in January, March and May 2022. Supportive testing of normal AFP and anti-HCV levels was performed with a positive result for HCV RNA >11.00. When considering liver function tests to assess liver disease severity using the CTP score, the score is 7 (CTP B). X-ray examination, CT scan and tumor size 11.2 x 6.7 cm were obtained, fed from the right a. hepatica, and there was no thrombosis in v. porta/hepatica. In these patients, there was no arterial enhancement, venous phase washout, and pseudocysts. The liver tumor of the aorta to the aorta, the largest size 7.3 x 11.3 x 15.9 cm, is equal to VTh11-VL3. The link expands to ±6.8 inches. Since the AFP test was normal and the CT scan did not show these results, this patient will be followed up with a biopsy. The biopsy method was performed with FNAB considering the safety of the procedure and the patient profile. Atypical FNAB results but favorable histochemistry for HCC, where CK, glypican-3, and AFP are positive. Based on the results of the examination, it was stated that the patient had Hepatoocellular Carcinoma (HCC) accompanied by cirrhosis of the liver due to chronic hepatitis C infection.