Correlation of Interleukin 6 Levels with C-Reactive Protein in Various Severity of Covid-19 Patients in Rsup Dr. Mohammad Hoesin Palembang

Abstract

COVID-19 is an acute infectious respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Changes in inflammatory mediators in the laboratory can be related to the phase of the disease course and the patient's clinical course. The results help determine the degree and predict the severity of COVID-19. This study aims to determine the correlation between Interleukin 6 levels and quantitative CRP levels to the severity of COVID-19 disease. This study is an analytic observational study with a cross-sectional design. This research was conducted in the COVID-19 isolation ward of RSMH Palembang from September 2021 to February 2022, with the subjects confirmed COVID-19 with various severity. Those confirmed with COVID-19 were interviewed, checked vital signs, laboratory tests for Interleukin 6, and quantitative CRP. Statistical analysis of the correlation test used Spearman and Gamma. Sample of 39 patients, consisting of 16 patients (41%) moderate, 15 patients (38.5%) severe, 8 patients (20.5%) critical. There was a significant correlation between interleukin six levels and the degree of COVID- a disease with r = 0.719. A positive correlation with moderate strength was found between interleukin six levels and quantitative CRP levels so that these two parameters can be used as predictors of the severity of COVID-19 and have a positive correlation.