The Effect of Giving Garlic Extract (Allium Sativum) on the Scoring of KDQOL-SF 36 Sub-Scale of Physical and Mental Health in Patients Treating Chronic Hemodialysis at Mohammad Hoesin General Hospital, Palembang

Abstract

Chronic kidney disease (CKD) patients undergoing hemodialysis have an increase in proinflammatory cytokines. The quality of life of chronic kidney disease patients undergoing hemodialysis is affected by inflammation. Assessment of quality of life in CKD is done using the Kidney Disease Quality of Life Short Form Survey 36 questionnaire (KDQOL SF-36). Garlic (Allium sativum) has anti-inflammatory components. This study was conducted to determine the effect of giving garlic extract on the KDQOL score of the physical and mental health subscale at Mohammad Hoesin General Hospital, Palembang. The study was conducted in the Hemodialysis Room of Moh Hoesin General Hospital, Palembang. Department of Internal Medicine, RSUP Dr.. Moh Hoesin Palembang met the inclusion criteria consecutively in January 2022. Statistical analysis was carried out using the SPSS version 25.0 program. A total of 40 subjects participated in the study, 60% of whom were male. The mean age in the garlic extract group was 45.5 (28-58), and in the placebo group, 55 (26-59). Characteristics of the KDQOL value of the SF-36 physical health subscale with a value of 45.75 ± 22.08 in the garlic group with a significant increase (p = 0.041), the KDQOL value of the SF-36 mental health subscale with a value of 63.26 ± 20.56 in the group garlic with a significant increase (p=0.001). Garlic extract was shown to reduce the inflammatory process, followed by an increase in the KDQOL SF-36 score on the physical and mental health subscale.