The Effect of Probiotics on Short Chain Fatty Acid Levels in Colorectal Cancer Patients Who Undergoing Chemotherapy at Dr. Mohammad Hoesin General Palembang Hospital

Abstract

Chemotherapy is the modality of colon cancer therapy that can reduce SCFA levels in the intestine. Probiotics are currently known to have a role in the pathogenesis of colon cancer and adjunct therapy for colon cancer patients. This study aims to examine the effect of probiotics on SCFA levels in faeces in colorectal cancer patients undergoing chemotherapy at RSMH Palembang; A randomized controlled trial in Hematology Oncology Policlinic between September 2021 and September 2022. The total number of subjects was 44, and then SCFA stool levels were examined at the study's beginning and end; Then, the analysis was carried out. About 37 subjects (19 probiotic group and 18 placebo groups) were analyzed, mean age was 45,62 ± 8,98 years. After intervention, the mean change of SCFA were 0.5786 ±3.887 mg/ml in probiotic group VS -2, 22 ±2.045 mg/mL (p-value 0.001). Probiotics have a significant effect on increasing SCFA levels in colorectal patients who were undergoing chemotherapy at Dr. Mohammad Hoesin General Palembang Hospital.