Association of Prostate Cancer and Lipid Profile: A Case-Control Study

Abstract

There are inconsistent findings concerning the association between the serum concentrations of lipid parameters and prostate cancer (PCa), particularly in Caucasian men. There is limited data on men of African ancestry. The study examined the relationship between serum total cholesterol (TC) levels and its fractions and PCa in a hospital-based case-control study in Jamaica. The serum levels of TC, triglycerides (TG), HDL-cholesterol (HDL-C), and LDL-cholesterol (LDL-C) in 46 male patients (cases) who underwent prostate biopsy were measured over an eighteen month period. There were 32 patients without PCa who served as controls. The serum lipid concentrations between cases and controls were compared using an independent samples t-test. Multiple linear regression and binary logistic regression were used to assess the relationship between lipids and overall PCa, as well as disease severity. Based on the results, there were no significant differences between the concentrations of lipids for the cases and controls. The results of the regression analysis revealed that the serum lipid levels were not significant predicators of overall PCa. The outcomes of the binary regression analysis showed the same for PCa severity. The study concluded that there was no association between serum levels of lipids and overall PCa as well as disease severity at the time of diagnosis in the sample of Jamaican men.