Comparison In-vitro Release and pH Effect Among Different Oral Antidiabetic Drugs: Review Article

Abstract

Diabetes is a metabolic condition that affects how the body utilizes digested food for growth and energy. The majority of the food we consume is broken down into glucose, which is the form of sugar in our blood. Glucose is the body's primary fuel source. The solubility of glibenclamide (glibenclamide), metformin, and sitagliptin were evaluated in triplicate in different pH using a water bath shaker at 37^oC using the shake-flask technique. The quantity of medicine accessible for absorption is determined by the drug release. Each drug's physiochemical characteristics substantially impact release along the G.I.T. For each medication, a calibration curve and solubility measurement were performed. In the duodenum and the small intestine, glibenclamide was released more efficiently and fast than metformin and sitagliptin, which had higher pK_a values than glibenclamide, i.e., the metformin and sitagliptin were released more quickly and efficiently in pH 1.2 and pH 5.8. Glibenclamide is absorbed from the stomach, if not completely.