Physiological and Molecular Characterization of “Hormonal Receptors and “HER-2/Neu” in Breast Cancer

Abstract

The hormonal, reproductive and demographic factors all affect the clinical course of breast cancer, which is an important health problem that remains unresolved. CAans and MVG: / Comparison of primary versus metastatic breast cancer characteristics This study aimed to evaluate the characteristics of PBC + MBC.  A descriptive analytical study was performed on the patients with primary and metastatic breast cancer to identify demographic, reproductive, clinical, histopathological, and hormonal factors.  The average age of the patients was 42 years. The incidence of primary breast cancer occurred at 51–55 years, whereas for metastatic disease, it was at 36–40 years. In 22.5% of primary patients, a history of AML was present and 35% had metastatic disease. Precocious menarche at 12–14 years has been described in 57% patients. The majority of patients were multiparous (75%) and 72% experienced their primiparity at or ≤25 years. Breast feeding accounted for 55.2% of primary and 47.1% of metastatic patients. The majority of patients were post-menopausal women. Incidence of axillary lymph nodes was 85% in primary and 80% in mets. Stage II was the most common (60%) followed by stage IV (26%). IDC accounted for the most common type of tumor (81%). Primary–metastatic sites, hormone receptors ER 67.8% and 54.66%, PR 66.6% and 63%; HER2Neu was significantly more positive in metastasis cases (62.7%) than in primaries (53.5%).  Breast cancer in the research population is early onset, and a high proportion of the cohort developed advanced disease. Reproductive factors and hormones, molecular tumor features have the tendency to shape the course of disease, emphasizing early diagnosis and personalized screening programs.