Relationship between Adipokines and Clinical Variables in Type 2 Diabetes Mellitus

Abstract

Adipokine secretion play a significant role in the onset of insulin resistance and diminished insulin activity in type 2 diabetes associated with obesity. Accumulation of excess body fat, especially visceral adiposity, is strongly correlated with a higher risk of cardiovascular complications due to underlying metabolic disturbances. The objective of the study was to examine the relationship between visceral fat-associated adipokines with clinical variables in central obese type 2 diabetic patients. Serum adipokine concentrations were determined using Enzyme-Linked Immunosorbent Assay (ELISA), while glycated hemoglobin (HbA1c) levels were assessed through High-Performance Liquid Chromatography (HPLC). All clinical parameters were evaluated following standardized procedures. The results indicate that the adipokines are significantly related (p < 0.05) to weight, body mass index (BMI) and waist circumference (WC) with varying degrees in central obese type 2 diabetic subjects. The adipokine levels are associated with clinical variables to a varying degree in central obese type 2 diabetic subjects. The effective target to control visceral fat-associated adipokines with clinical variables reduces body weight, obesity, visceral fat and cardiovascular risk in type 2 diabetes.