Design and Optimization of Elanzapine Drug Release with Polyoxazoline Based Hydrogel

Abstract

Due to the fact that Elanzapine is prescribed orally and by injection for psychotic and schizophrenic disorders, and depending on the type of disease, these people are prevented from swallowing the drug; therefore, checking the injectable form of the drug with controlled release, which increases the release of the drug to one week with a single injection, is important. On the other hand, one of the most important biodegradable polymers that have the adhesive property of Elanzapine is Polyoxazoline, so the aim of this study is to design a slow release system, considering the short half-life of this drug and the need for a large number of doses and the patient's lack of cooperation for treatment. The drug is based on Polyoxazoline, which can reduce the consumption and, consequently, the toxicity and accumulation of the drug in the body. Mathematical heart direction, the forecast of different conditions will be presented, and also obtaining the optimal conditions and the final formulation is one of the main goals of this study. In this research, the release of olanzapine on the matrix loaded with olanzapine, the morphological characteristics of the matrix, the thermal characteristics of the matrix and the rheological characteristics of the matrix have been investigated. The release of olanzapine in the examined gels lasted for more than 168 hours, which was a sign of the slow release system, which is the main goal of this project. Several models were used to investigate the release kinetics of olanzapine, and among them, the Higuchi equation showed the best degree of regression with experimental data. By increasing the percentage of Elanzapine, the process of changes in viscosity goes out of the linear state; on the other hand, the difference between the optimum matrix viscosity of 3 and 4% of Elanzapine is small.