The Theoretical Synthesis and in silico Modelling of Lysergic Acid Biscinnamylidene Amide from the Adduct Formation of d-Lysergic Acid Amide and Cinnamaldehyde

Abstract

Here is a theoretical synthesis for a cinnamaldehyde adduct formation of a hypothetically proposed lysergamide derivative named cinnamylidene-bislysergamide or lysergic acid biscinnamylidene amide (LSBC). This lysergamide name and abbreviation is in keeping with names of other lysergamide derivatives, such as d-lysergic acid amine (LSA), lysergic acid 2-butyl amide (LSB), lysergic acid diethylamide (LSD), d-lysergic acid α-hydroxyethylamide (LSH), lysergic acid methylisopropylamide (LSMIP), and lysergic acid 3-pentyl amide (LSP). Lysergamides are generally psychedelic in nature. The evidence for LSBC adduct formation is plausible, but the evidence supporting its psychedelic effects is weak.