The Theoretical Synthesis and in silico Modelling of Lysergic Acid Biscinnamylidene Amide from the Adduct Formation of d-Lysergic Acid Amide and Cinnamaldehyde

cinnamylidene-bislysergamide cinnamylidene-bislysergic acid amide CBLSA LSC LSBC adduct LSA LSH d-lysergic acid amide


  • Victor Chiruta
    School of Health Sciences, University of South Australia, 101 Currie St, Adelaide, SA 5001, AU; Independent Food & Therapeutic Authority, M/134 Great Western Hwy, Blaxland, NSW 2774, AU; Mind Medicine Australia, 1/10 Dorcas St, South Melbourne, VIC 3205, AU
March 5, 2022


Here is a theoretical synthesis for a cinnamaldehyde adduct formation of a hypothetically proposed lysergamide derivative named cinnamylidene-bislysergamide or lysergic acid biscinnamylidene amide (LSBC). This lysergamide name and abbreviation is in keeping with names of other lysergamide derivatives, such as d-lysergic acid amine (LSA), lysergic acid 2-butyl amide (LSB), lysergic acid diethylamide (LSD), d-lysergic acid α-hydroxyethylamide (LSH), lysergic acid methylisopropylamide (LSMIP), and lysergic acid 3-pentyl amide (LSP). Lysergamides are generally psychedelic in nature. The evidence for LSBC adduct formation is plausible, but the evidence supporting its psychedelic effects is weak.